We examined the effect of exercise on postprandial lipemia (PPL) and insulin resistance in individuals with metabolic syndrome. Subjects were 10 hypertriglyceridemia (HTG) males with insulin resistance [age = 40.1 +/- 2.2 years, body weight = 96.3 +/- 3.3 kg, fasting triglyceride (TG) = 263 +/- 25 mg/dl, VO(2)max = 37 +/- 1.1 ml/kg/min, and Homeostatic Model Assessment (HOMA-IR, an index of insulin resistance) = 3.05 +/- 0.40]. Each subject performed a control trial (Ctr, no exercise), and three exercise trials at 40% (40%T), 60% (60%T), and 70% (70%T) of their VO(2)max. The order of trials was randomized and there were 1-2 weeks wash-out period between the trials. All subjects had a fat-meal in each trial. In the exercise trials, subjects jogged on a treadmill for 1 h at a designated intensity 12 h prior to a fat-meal ingestion. Blood samples were taken at 0 h (before the meal), and 2, 4, 6, and 8 h after the meal. The plasma TG, area score under TG concentration curve for over an 8 h-period (TG AUC) after the meal, and HOMA-IR were analyzed. The TG AUC score in 40%T was 30% lower (P = 0.003), 60%T was 31% lower (P = 0.02), and 70%T was 39% lower (P = 0.02) than Ctr. There were no significant differences in the TG AUC scores among the exercise trials (P > 0.05). The insulin concentrations in both 60 and 70%T were lower than Ctr (P < 0.01) which did not differ from 40%T. HOMA-IR in both 60%T (P = 0.041) and 70%T (P = 0.002) were lower than Ctr, but not different from 40%T (HOMA-IR: Ctr = 3.05 +/- 0.40, 40%T = 2.67 +/- 0.35, 60%T = 2.49 +/- 0.31, 70%T = 2.21 +/- 0.27). The results suggest that for physically inactive individuals with metabolic syndrome, exercising at low to moderate intensity may be sufficient to attenuate PPL and increase insulin sensitivity, whereas higher intensity exercise may be needed to normalize blood glucose.

译文

:我们研究了运动对代谢综合征患者餐后血脂(PPL)和胰岛素抵抗的影响。受试者为10名高甘油三酸酯血症(HTG)男性,其胰岛素抵抗[年龄= 40.1 /-2.2岁,体重= 96.3 /-3.3 kg,空腹甘油三酸酯(TG)= 263 /-25 mg / dl,VO(2)max = 37 -/-1.1 ml / kg / min,并且稳态模型评估(HOMA-IR,胰岛素抵抗指数)= 3.05-0.40]。每个受试者进行了一项对照试验(Ctr,无运动),并进行了三项运动试验,试验的最大VO(2)最大为40%(40%T),60%(60%T)和70%(70%T)。试验顺序是随机的,两次试验之间有1-2周的清除期。所有受试者在每次试验中均吃一顿胖饭。在运动试验中,受试者在摄入脂肪餐之前12小时以指定的强度在跑步机上慢跑1小时。在0小时(饭前),饭后2、4、6和8小时采集血样。餐后8 h(TG AUC),血浆TG,TG浓度曲线下的面积得分和HOMA-IR进行了分析。与Ctr相比,在40%T中的TG AUC得分降低了30%(P = 0.003),在60%T中降低了31%(P = 0.02),在70%T中降低了39%(P = 0.02)。在运动试验之间,TG AUC评分无显着差异(P> 0.05)。 60%和70%T中的胰岛素浓度均低于Ctr(P <0.01),与40%T无差异。 60%T(P = 0.041)和70%T(P = 0.002)的HOMA-IR均低于Ctr,但与40%T相同(HOMA-IR:Ctr = 3.05 /-0.40,40%T = 2.67 /-0.35,60%T = 2.49 /-0.31,70%T = 2.21 /-0.27)。结果表明,对于缺乏运动能力的代谢综合征患者,低强度至中等强度的运动可能足以减弱PPL和增加胰岛素敏感性,而可能需要更高强度的运动才能使血糖正常化。

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