The Z-Scan (ZS) technique in the thermal regime has been used to measure the nonlinear optical response of low-density lipoprotein (LDL). The ZS technique is carried out in LDL from 40 patients with chronic periodontitis before and after three, six, and 12 months of periodontal treatment. Clinical parameters such as probing depths, bleeding on probing, total and differential white blood cells counts, lipid profiles, cytokine levels, and antibodies against oxidized LDL are also determined and compared over time. Before the treatment, the ZS experimental results reveal that the LDL particles of these patients are heavily modified. Only after 12 months of the periodontal treatment, the ZS results obtained reveal behavioral characteristics of healthy particles. This conclusion is also supported by complementary laboratorial analysis showing that the periodontal treatment induces systemic changes in several inflammatory markers.

译文

热状态下的Z扫描 (ZS) 技术已用于测量低密度脂蛋白 (LDL) 的非线性光学响应。ZS技术是在牙周治疗3、6和12个月之前和之后对40例慢性牙周炎患者的LDL进行的。还可以确定临床参数,例如探测深度,探测出血,白细胞总数和差异计数,脂质分布,细胞因子水平以及针对氧化LDL的抗体,并随时间进行比较。治疗前,ZS实验结果表明,这些患者的LDL颗粒已被严重修饰。仅在牙周治疗12个月后,获得的ZS结果才显示出健康颗粒的行为特征。该结论也得到补充实验室分析的支持,该分析表明牙周治疗可引起几种炎症标志物的全身变化。

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