The Shozu Herpes Zoster (SHEZ) Study was designed to clarify the incidence of and predictive and immunological factors for herpes zoster in a defined community-based Japanese population. As part of this series, a total of 5683 residents aged ≥50 years received a varicella-zoster virus (VZV) skin test with VZV antigen, and 48 h later, the erythema and oedema were assessed by measuring the longest diameter. The diameters of both the erythema and oedema decreased with the increasing age of the subject. Sixty-three subjects contracted herpes zoster within a year after receiving the VZV skin test. Analysis of the herpes zoster incidence rate vs. the skin test reaction revealed that the shorter the diameter of erythema or oedema, the greater the likelihood of herpes zoster. These results demonstrated that the VZV skin test is an excellent surrogate marker for predicting the risk of herpes zoster.

译文

Shozu带状疱疹 (SHEZ) 研究旨在阐明以社区为基础的日本人群中带状疱疹的发生率以及预测和免疫学因素。作为本系列的一部分,共有5683名年龄 ≥ 50岁的居民接受了VZV抗原的水痘病毒 (VZV) 皮肤测试,48小时后,通过测量最长直径来评估红斑和水肿。随着受试者年龄的增长,红斑和水肿的直径均减小。接受VZV皮肤测试后一年内,有63名受试者感染了带状疱疹。对带状疱疹发病率与皮肤测试反应的分析表明,红斑或水肿的直径越短,带状疱疹的可能性越大。这些结果表明,VZV皮肤测试是预测带状疱疹风险的出色替代指标。

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