We examined the role of dietary calcium and vitamin D intakes in childhood and throughout adulthood in relation to mammographic density using data from a nationally representative cohort of 1161 women followed up since their birth in 1946. Dietary intakes at the age of 4 years were determined by 24-h recalls and at the ages of 36, 43 and 53 years by 5-day food records. After adjusting for known risk factors and confounders, no evidence of a relationship between dietary calcium or vitamin D intakes and mammographic density approximately at the age of 50 years was found, except for a cross-sectional relationship between dietary calcium intake at the age of 53 years and breast density in women who were post-menopausal at the time of mammography, with those in the top fifth of the distribution of calcium intake having a 0.53 s.d. lower percent breast density than those in the lowest fifth (P-value <0.01 for linear trend).

译文

:我们使用1161名自1946年出生以来一直接受随访的全国代表性队列研究的数据,研究了儿童期和整个成年期饮食中钙和维生素D摄入量与乳腺摄影密度之间的关系。确定了4岁以下儿童的饮食摄入量通过24小时的召回记录,并通过5天的食物记录分别记录了36岁,43岁和53岁的年龄。在调整了已知的危险因素和混杂因素后,除53岁时饮食钙摄入量之间的横断面关系外,未发现饮食中钙或维生素D摄入量与乳房X线照片密度之间存在关系的证据(约50岁)。乳房X线摄影时绝经后妇女的年数和乳房密度,钙摄入量分布的前五分之一的妇女为0.53 sd相比最低的第五位人群,乳腺密度百分比更低(线性趋势P值<0.01)。

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