This study investigates the incidence trends of urinary bladder cancer in Sweden from 1960 through 1993 (a total of 46,211 cases). Age-standardized incidence rates increased among men from 14.6 per 10(5) in 1960 to 33.5 in 1993 and among women from 4.8 to 8.8, corresponding to an average annual increase of 2.4 percent (95 percent confidence interval [CI]) = 2.0-2.7 percent) and 1.1 percent (CI = 0.9-1.4 percent), respectively. The largest increase occurred in the oldest age-groups. The proportion of patients with transitional cell carcinoma increased in men from 66.0 percent in 1960-64 to 93.6 percent in 1990-93 and in women from 61.0 percent to 89.4 percent. The proportion of patients with papillomas decreased, whereas those with adenocarcinoma and squamous cell carcinoma were stable. Regression modeling (based on the period 1960-89) showed a strong linear effect due to either period and/or cohort. Among men, additional non-linear effects by both period and cohort were obtained. The cohort effects were more important. Cohort data on having smoked daily showed considerable similarities with the estimated cohort-effects. Our findings suggest that the increase of tobacco smoking in successive generations can explain the increase in incidence rates of bladder cancer in Sweden, whereas improved diagnostic activities and registration are less likely to explain fully the changes in incidence rates.

译文

这项研究调查了瑞典从1960年到1993年的膀胱癌的发病趋势(共46,211例)。男性的年龄标准化发病率从1960年的每10(5)中的14.6增加到1993年的33.5,女性从4.8增加到8.8,相当于每年平均增长2.4%(95%置信区间[CI])= 2.0-分别为2.7%和1.1%(CI = 0.9-1.4%)。增长最大的是年龄最大的年龄组。男性中移行细胞癌患者的比例从1960-64年的66.0%增加到1990-93年的93.6%,女性从61.0%增加到89.4%。乳头状瘤患者的比例下降,而腺癌和鳞状细胞癌患者的比例稳定。回归建模(基于1960-89年期间)由于周期和/或同类群组而显示出强大的线性效应。在男性中,通过周期和队列均获得了额外的非线性效应。队列效应更为重要。每天吸烟的队列数据显示与估计的队列效应有很大的相似性。我们的发现表明,连续几代吸烟的增加可以解释瑞典膀胱癌的发病率增加,而诊断活动和登记的改善不太可能完全解释发病率的变化。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录