OBJECTIVE:The present study investigates associations between brain white matter tract integrity and cognitive abilities in community-dwelling older people (N = 655). We explored two potential confounds of white matter tract-cognition associations in later life: (a) whether the associations between tracts and specific cognitive abilities are accounted for by general cognitive ability (g); and (b) how the presence of atrophy and white matter lesions affect these associations. METHOD:Tract integrity was determined using quantitative diffusion magnetic resonance imaging tractography (tract-averaged fractional anisotropy [FA]). Using confirmatory factor analysis, we compared first-order and bifactor models to investigate whether specific tract-ability associations were accounted for by g. RESULTS:Significant associations were found between g and FA in bilateral anterior thalamic radiations (r range: .16-.18, p < .01), uncinate (r range: .19-.26, p < .001), arcuate fasciculi (r range: .11-.12, p < .05), and the splenium of corpus callosum (r = .14, p < .01). After controlling for g within the bifactor model, some significant specific cognitive domain associations remained. Results also suggest that the primary effects of controlling for whole brain integrity were on g associations, not specific abilities. CONCLUSION:Results suggest that g accounts for most of, but not all, the tract-cognition associations in the current data. When controlling for age-related overall brain structural changes, only minor attenuations of the tract-cognition associations were found, and these were primarily with g. In totality, the results highlight the importance of controlling for g when investigating associations between specific cognitive abilities and neuropsychology variables.

译文

目的:本研究调查了居住在社区的老年人(N = 655)中脑白质束完整性与认知能力之间的关系。我们探讨了晚年白质物质与认知的关联的两个潜在的混淆:(a)物质与特定认知能力之间的关联是否由一般认知能力(g)解释; (b)萎缩和白质病变的存在如何影响这些关联。
方法:使用定量扩散磁共振成像体层摄影术(区域平均分数各向异性[FA])确定道的完整性。使用验证性因素分析,我们比较了一阶和双因素模型,以调查特定的道能力关联是否由g解释。
结果:在双侧丘脑前部辐射中,g和FA之间存在显着相关性(r范围:.16-.18,p <.01),单核(r范围:.19-.26,p <.001),弓状筋膜(r范围:.11-.12,p <.05)和call体脾(r = .14,p <.01)。在双因素模型中控制g之后,仍然存在一些重要的特定认知域关联。结果还表明,控制全脑完整性的主要作用是对g的联想,而不是特定的能力。
结论:结果表明,g占了当前数据中大部分但并非全部的道认知关联。当控制与年龄相关的整体大脑结构变化时,仅发现了道认知关联的轻微衰减,而这些衰减主要与g有关。总体而言,这些结果凸显了在调查特定认知能力与神经心理学变量之间的关联时,控制g的重要性。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录