Background:Colorectal cancer is known to be the most common type of cancer worldwide with high disease-related mortality. It is the third most common cancer in men and women and is the second major cause of death globally due to cancer. It is a complicated and fatal disease comprising of a group of molecular heterogeneous disorders. Results:This study identifies the potential biomarkers of CRC through differentially expressed analysis, system biology, and proteomic analysis. Ten publicly available microarray datasets were analyzed and seven potential biomarkers were identified from the list of differentially expressed genes having a p value < 0.05. The expression profiling and the functional enrichment analysis revealed the role of these genes in cell communication, signal transduction, and immune response. The protein-protein interaction showed the functional association of the source genes (CTNNB1, NNMT, PTCH1, CALD1, CXCL14, CXCL8, and TNFAIP3) with the target proteins, such as AXIN, MAPK, IL6, STAT, APC, GSK3B, and SHH. Conclusion:The integrated pathway analysis indicated the role of these genes in important physiological responses, such as cell cycle regulation, WNT, hedgehog, MAPK, and calcium signaling pathways during colorectal cancer. These pathways are involved in cell proliferation, chemotaxis, cellular growth, differentiation, tissue patterning, and cytokine production. The study shows the regulatory role of these genes in colorectal cancer and the pathways that can be effected after the dysregulation of these genes.

译文

背景:结直肠癌是世界范围内最常见的癌症,与疾病相关的死亡率很高。它是男女中第三大最常见的癌症,并且是全球因癌症而导致死亡的第二大原因。它是一种复杂且致命的疾病,由一组分子异质性疾病组成。
结果:本研究通过差异表达分析,系统生物学和蛋白质组学分析鉴定了CRC的潜在生物标志物。分析了十个公开可用的微阵列数据集,并从p值<0.05的差异表达基因列表中鉴定了七个潜在的生物标记。表达谱和功能富集分析揭示了这些基因在细胞通讯,信号转导和免疫应答中的作用。蛋白质相互作用显示源基因(CTNNB1,NNMT,PTCH1,CALD1,CXCL14,CXCL8和TNFAIP3)与目标蛋白质(例如AXIN,MAPK,IL6,STAT,APC,GSK3B和SHH)之间存在功能关联。
结论:综合通路分析表明这些基因在大肠癌的重要生理反应中的作用,例如细胞周期调控,WNT,刺猬,MAPK和钙信号通路。这些途径涉及细胞增殖,趋化性,细胞生长,分化,组织模式和细胞因子产生。研究表明这些基因在结直肠癌中的调节作用以及这些基因失调后可能发生的途径。

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