Two varieties of collagen/sodium hyaluronan membranes were used as dermal substitutes in a biocompatibility implantation study on rats. In order to improve especially the physical and mechanical properties of the material, the membranes were chemically modified using a combination of hexamethylenediisocyanate (HMDC) as a crosslinker and polyoxy-ethylene (POE) as a spacer. According to both macroscopic and microscopic histological observations, the membranes were well accepted by the surrounding host tissue in all the animals. No major differences in relation to the outgrowth of the material by host tissue have been observed between the implant varieties A and B. The most important finding was that no pathological changes or important alterations of the host tissues were detected.

译文

:在大鼠的生物相容性植入研究中,使用了两种胶原/透明质酸钠膜作为真皮替代物。为了特别提高材料的物理和机械性能,使用六亚甲基二异氰酸酯(HMDC)作为交联剂和聚氧乙烯(POE)作为间隔物的组合对膜进行了化学修饰。根据宏观和微观组织学观察,在所有动物中,膜都被周围宿主组织很好地接受。在植入物品种A和B之间,没有观察到与宿主组织的材料生长有关的主要差异。最重要的发现是未检测到宿主组织的病理变化或重要变化。

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