Alteration in the chemical composition of a biomaterial may be undertaken to improve its biological properties. The aim of this work was to evaluate the biocompatibility of three chemical compositions of Ricinus communis polyurethane (RCP): RCPp (pure RCP), RCP + CaCO(3), and RCP +Ca(3)(PO(4))(2). RCP cylinders were surgically implanted in rabbit femurs. After 8, 12, and 16 weeks, the femurs were removed, fixed, sectioned, ground, and stained by Stevenel's blue/Alizarin red S for light microscopy and histomorphometry. The osseointegration and osseoconductivity were calculated by means of image analysis and the data were submitted to the Kruskal-Wallis test followed by Dunn's test. Osseointegration was already completed after 8 weeks on RCP + Ca(3)(PO(4))(2) because similar values were found from week 8 to 16, whereas it showed a time-dependent increase on RCPp and RCP +CaCO(3). The osseointegration was greater on RCP + Ca(3)(PO(4))(2) in all periods when compared with RCPp, and after 8 and 12 weeks when compared with RCP + CaCO(3). None of the RCP samples presented osseoconductivity. The present results showed that RCP blended with calcium phosphate improved the biocompatibility by both enhancing and accelerating its osseointegration. Based on the absence of osseoconductivity, RCP was considered to be a bioinert material.

译文

:可以通过改变生物材料的化学组成来改善其生物学特性。这项工作的目的是评估蓖麻聚氨酯(RCP)的三种化学成分的生物相容性:RCPp(纯RCP),RCP CaCO(3)和RCP Ca(3)(PO(4))(2)。将RCP圆柱体通过外科手术植入兔股骨中。 8、12和16周后,取股骨,固定,切片,磨碎,并用史蒂文尔氏蓝/茜素红S染色,以进行光学显微镜检查和组织形态学测定。通过图像分析计算骨整合和骨电导率,并将数据提交给Kruskal-Wallis检验,然后进行Dunn检验。在8周后,RCP Ca(3)(PO(4))(2)上的骨整合已经完成,因为从第8周到第16周发现了相似的值,而RCPp和RCP CaCO(3)随时间增加。与RCPp相比,RCP Ca(3)(PO(4))(2)在所有时期的骨整合都更大,与RCP CaCO(3)相比在8周和12周之后。没有RCP样品表现出骨电导率。目前的结果表明,RCP与磷酸钙共混可通过增强和加速其骨整合来改善生物相容性。基于不存在骨导电性,RCP被认为是一种生物惰性材料。

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