Chemical combinations of Ca-P produced via plasma electrolytic oxidation (PEO) and a hydrothermal treatment were fabricated to improve the initial corrosion resistance and biocompatibility of a biodegradable Mg-3Al-1Zn-1.5Ca alloy. For the formation of an amorphous calcium phosphate composite layer on the surface of a magnesium alloy, a PEO layer composed of MgO and Mg3(PO4)2 was formed by PEO in electrolytes containing preliminary phosphate ions. During the second stage, a thick and dense Ca layer was formed by Ca electrodeposition after PEO. Finally, a hydrothermal treatment was carried out for chemical incorporation of P ions in the PEO layer and Ca ions in the electrodeposition layer. The amorphous calcium phosphate composite layer formed by the hydrothermal treatment enhanced osteoblast activity and reduced H2O2 production, which is a known stress indicator for cells. As a result of co-culturing osteoblast cells and RAW 264.7 cells, the formation of amorphous calcium phosphate increased osteoblast cell differentiation and decreased osteoclast cell differentiation. Implanting the alloy, which had an amorphous calcium phosphate composite layer that had been added through hydrothermal treatment, in the tibia of rats led to a reduction in initial biodegradation and promoted new bone formation.

译文

:制造了通过等离子电解氧化(PEO)和水热处理产生的Ca-P的化学组合,以改善可生物降解的Mg-3Al-1Zn-1.5Ca合金的初始耐腐蚀性和生物相容性。为了在镁合金的表面上形成非晶质磷酸钙复合层,在含有初级磷酸根离子的电解质中,通过PEO形成由MgO和Mg3(PO4)2构成的PEO层。在第二阶段中,PEO后通过电沉积Ca形成厚而致密的Ca层。最后,进行水热处理以化学结合PEO层中的P离子和电沉积层中的Ca离子。通过水热处理形成的无定形磷酸钙复合层增强了成骨细胞活性并减少了H2O2的产生,这是细胞已知的应激指标。共培养成骨细胞和RAW 264.7细胞的结果是,无定形磷酸钙的形成增加了成骨细胞的分化并降低了破骨细胞的分化。将具有通过水热处理添加的无定形磷酸钙复合层的合金植入大鼠胫骨,可减少初始生物降解并促进新骨的形成。

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