The use of biocompatible materials has attained an increasing importance for tissue regeneration and transplantation. The excellent mechanical and corrosion properties of Ti40Cu38Zr10Pd12 bulk metallic glass (BMG) turn it into a potential candidate for its use in orthopaedic implants. Before being considered as a biomaterial, some biological parameters must be taken into account. In this study,mouse preosteoblasts were cultured in the presence or absence of the alloy at different times (24 h, 7 and 21 days) and no differences in cell viability were detected.Moreover, cells were able to adhere to the alloy surface by establishing focal contacts, and displayed a flattened polygonal morphology. After 14 days in culture, differentiation into osteoblasts was observed. Besides, the amount of Cu ions released and their potential toxic effects were analyzed, showing that the amount of Cu released did not increase cell death. Finally, the low levels of inflammatory cytokines secreted by THP-1 differentiated macrophages exposed to the alloy suggest the absence of an immunogenic response to the alloy. In conclusion, in vitro studies indicate that the Ti40Cu38Zr10Pd12 BMG could be considered as a biomaterial to be used in orthopaedic implants.

译文

生物相容性材料的使用对于组织再生和移植越来越重要。 Ti40Cu38Zr10Pd12大块金属玻璃(BMG)的出色的机械和耐腐蚀性能使其成为骨科植入物的潜在候选者。在被考虑为生物材料之前,必须考虑一些生物学参数。在这项研究中,在不同时间(24小时,7天和21天)在有或没有合金的情况下培养小鼠成骨细胞,没有发现细胞活力的差异。焦点接触,并显示出扁平的多边形形态。培养14天后,观察到分化为成骨细胞。此外,分析了铜离子的释放量及其潜在的毒性作用,表明铜离子的释放量不会增加细胞死亡。最后,暴露于合金的THP-1分化巨噬细胞分泌的炎性细胞因子水平低,表明对合金缺乏免疫原性应答。总之,体外研究表明,Ti40Cu38Zr10Pd12 BMG可被认为是用于整形外科植入物的生物材料。

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