Biocompatible and biodegradable polyurethanes were prepared with fixed aliphatic diisocyanate level and varying ratios of isosorbide, and PCL diol via a simple one-shot polymerization without a catalyst. The successful synthesis of the polyurethanes was confirmed by gel permeation chromatography, (1)H-nuclear magnetic resonance and Fourier transform-infrared spectroscopies and the thermal properties were determined by differential scanning calorimetry and showed glass transition temperatures of around 30-35 °C. The degradation tests were performed at 37 °C in phosphate buffer solution (approx. pH 7.3) and showed a mass loss of around 5 % after 12 weeks, except for the polymer with the highest isosorbide content which showed an initial rapid mass loss. The in vitro cytocompatibility test results following culture of osteoblasts on the polymer surface showed that relative cell number on all of the polyurethane films after 5 days of cultured on polymer films was lower compared to the proliferation rate on the optimized tissue culture plastic. These polymers offer significant promise due to the simplicity of the synthesis and the controlled degradation.

译文

:通过固定的脂肪族二异氰酸酯含量和不同比例的异山梨醇与PCL二醇的生物相容性和可生物降解聚氨酯,可通过一次简单的一次聚合而无需催化剂。通过凝胶渗透色谱法,(1)H-核磁共振和傅立叶变换红外光谱法证实了聚氨酯的成功合成,并且通过差示扫描量热法测定了热性质,并且显示出约30-35℃的玻璃化转变温度。降解测试在磷酸盐缓冲溶液(约pH 7.3)中于37°C进行,显示12周后质量损失约为5%,但异山梨醇含量最高的聚合物显示出最初的快速质量损失。在聚合物表面培养成骨细胞后的体外细胞相容性测试结果表明,与在优化的组织培养塑料上的增殖速率相比,在聚合物膜上培养5天后,所有聚氨酯膜上的相对细胞数均较低。由于合成的简单性和受控的降解,这些聚合物提供了重要的前景。

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