Tooth agenesis is a common craniofacial congenital malformation in humans, but little is known about the mechanisms of root resorption in this condition. The purpose of this study was to investigate the mechanisms of root resorption in primary molars without successors. An animal model without permanent tooth germs was established by surgery in beagles. The times of onset of primary molar root resorption, with and without successors, were compared. The distribution of immune cells, odontoclasts, and their activating factors were determined by histochemistry and immunohistochemistry. Root resorption of primary mandibular molars without successors began later than physiological resorption. In primary molars without permanent germs, odontoclasts and immune cells were present mainly in the apical pulp at the start of root resorption, whereas in control teeth receptor activator of nuclear factor-κB ligand (RANKL)-positive cells were found mainly in the region of the periodontal ligament. CD14(+) and CD3(+) cells were found in both the pulp and the periodontal ligament region. These results suggest that the dental pulp of primary molars, as well as immune cells, may play an important role in root resorption in primary molars without permanent tooth germs.

译文

牙齿发育不全是人类常见的颅面先天性畸形,但对这种情况下的牙根吸收机制知之甚少。目的探讨无后继磨牙根吸收的机制。通过手术在小猎犬中建立了没有恒牙病菌的动物模型。比较了有和没有后继的初级磨牙根吸收的开始时间。通过组织化学和免疫组织化学确定免疫细胞,牙本质细胞及其激活因子的分布。没有后继的下颌磨牙的根部吸收比生理吸收晚。在没有永久性细菌的初级磨牙中,牙本质细胞和免疫细胞主要存在于牙根吸收开始时的根尖牙髓中,而在对照牙齿中,核因子-κ b配体 (RANKL) 阳性细胞的受体激活剂主要存在于牙周膜区域。在牙髓和牙周膜区域均发现CD14 () 和CD3 () 细胞。这些结果表明,在没有恒牙病菌的初级磨牙中,初级磨牙的牙髓以及免疫细胞可能在牙根吸收中起重要作用。

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