The absorption characteristics of vitamin E acetate (VEA) formulated into a dry emulsion system after its oral administration to beagle dogs were determined and compared to those of two different dosage forms (an oily mixture of the drug with cottonseed oil and an oil (drug)-in-water emulsion). The three dosage forms were administered in a crossover fashion to six nonfasting subjects, and the drug absorption was assessed from the plasma concentration of the major metabolite (free vitamin E). VEA formulated in the dry emulsion was rapidly absorbed, which suggested that a considerable amount was released as reformed emulsion droplets in the gastrointestinal tract as well as in water in vitro. Based on the analysis of variance, no significant differences in bioavailability parameters (AUC, Cmax or Tmax) were observed among the three dosage forms.

译文

测定了口服给比格犬后配制成干乳液系统的维生素e乙酸酯 (VEA) 的吸收特性,并将其与两种不同剂型 (药物与棉籽油和油 (药物) 的油性混合物) 的吸收特性进行了比较。-水包乳液)。以交叉方式向六名非禁食受试者施用三种剂型,并根据主要代谢物 (游离维生素e) 的血浆浓度评估药物吸收。配制在干燥乳剂中的VEA被迅速吸收,这表明在胃肠道以及体外水中以重整乳剂液滴的形式释放了大量。根据方差分析,在三种剂型之间未观察到生物利用度参数 (AUC,Cmax或Tmax) 的显着差异。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录