BACKGROUND & AIMS:
:Five dichlorinated 8-quinolinols (2,5- 5,6-, 3,5-, 3,7-, and 4,5-dichloro-8-quinolinol) were tested against Candida albicans and C. tropicalis in Sabouraud dextrose broth with and without bovine serum. The 5,6-, 3,5-, and 3,7-dichloro-8-quinolinols proved to be more effective than the control, 5-fluorocytosine. In cytotoxicity tests employing baby hamster kidney (BHK) cells, all test agents proved to be more cytotoxic than the control. However, the minimum inhibitory concentration (MIC) of 3,5-dichloro-8-quinolinol to both fungi was only one tenth the cytotoxic dose, suggesting that the compound may be useful as a topical or systemic antifungal agent.
背景与目标:
:在Sabouraud葡萄糖肉汤中测试了五种二氯8-喹啉醇(2,5- 5,6-,3,5-,3,7-和4,5-二氯8-喹啉醇)对白色念珠菌和热带念珠菌的抵抗力有和没有牛血清。 5,6-,3,5-和3,7-二氯-8-喹啉醇被证明比对照的5-氟胞嘧啶更有效。在使用小仓鼠肾脏(BHK)细胞的细胞毒性测试中,所有测试药物均被证明比对照更具细胞毒性。但是,3,5-二氯-8-喹啉醇对两种真菌的最小抑制浓度(MIC)仅是细胞毒性剂量的十分之一,表明该化合物可用作局部或全身性抗真菌剂。