Human infections with Nipah virus in Malaysia and Bangladesh are associated with markedly different patterns of transmission and pathogenicity. To compare the 2 strains, we conducted an in vivo study in which 2 groups of ferrets were oronasally exposed to either the Malaysia or Bangladesh strain of Nipah virus. Viral shedding and tissue tropism were compared between the 2 groups. Over the course of infection, significantly higher levels of viral RNA were recovered from oral secretions of ferrets infected with the Bangladesh strain. Higher levels of oral shedding of the Bangladesh strain of Nipah virus might be a key factor in onward transmission in outbreaks among humans.

译文

马来西亚和孟加拉国的人感染Nipah病毒与明显不同的传播和致病性有关。为了比较这两种菌株,我们进行了一项体内研究,其中两组雪貂口服暴露于马来西亚或孟加拉国尼帕病毒株。比较两组之间的病毒脱落和组织嗜性。在感染过程中,从感染孟加拉国菌株的雪貂的口腔分泌物中回收了明显更高水平的病毒RNA。孟加拉国Nipah病毒株的口服脱落水平较高可能是人类爆发后继续传播的关键因素。

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