OBJECTIVE:To determine the prevalence and characteristics of myocardial dysfunction and other cardiac manifestations in acutely ill hospital patients infected with human immunodeficiency virus (HIV) in Zimbabwe. DESIGN:A prospective echocardiographic survey of acutely ill HIV seropositive patients. SETTING:General medical ward, Harare Central Hospital, Zimbabwe. PATIENTS:One hundred and fifty seven HIV seropositive patients admitted with various acute medical conditions over a 12 month period, January to December 1994. MAIN OUTCOME MEASURES:Detection of myocardial dysfunction and other cardiac abnormalities by cross sectional echocardiography. RESULTS:Eighty (51%) men and 77 women were studied (mean (SD) age 34.4 (8.5), range 15-60 years for males and 31.6 (9.0), range 16-65 years for females). They were all heterosexual. None was haemophiliac or an intravenous drug user. Echocardiographic abnormalities were found in 79 (50%) patients: 14/151 (9%) had dilated cardiomyopathy, 33/151 (22%) left ventricular dysfunction, 9/151 isolated right ventricular dilatation, and 30/157 (19%) pericardial disease (28 with effusions, three having tamponade). There were two cases of constrictive pericarditis and one of ascending aortic aneurysm. CONCLUSIONS:There is a high prevalence of echocardiographically detected myocardial and pericardial disease in this group of acutely ill HIV infected patients. Left ventricular dysfunction without dilatation was common, but its significance was not ascertained.

译文

目的:确定津巴布韦感染人类免疫缺陷病毒(HIV)的急症医院患者的心肌功能障碍和其他心脏表现的患病率和特征。
设计:对急性病HIV血清反应阳性患者的前瞻性超声心动图调查。
地点:津巴布韦哈拉雷中央医院普通病房。
患者:1994年1月至12月的12个月期间,有157名HIV血清反应阳性的患者接受了各种急性医疗条件治疗。
主要观察指标:横断面超声心动图检测心肌功能障碍和其他心脏异常。
结果:研究了80名(51%)男性和77名女性(平均(SD)年龄34.4(8.5),男性15-60岁,女性31.6(9.0),女性16-65岁)。他们都是异性恋。没有人是血友病患者或静脉吸毒者。在79名(50%)患者中发现了超声心动图异常:14/151(9%)患有扩张型心肌病,33/151(22%)左心功能不全,9/151单独的右心室扩张和30/157(19%)心包疾病(28例有积液,三例有填塞物)。缩窄性心包炎2例,升主动脉瘤1例。
结论:在这组急性感染艾滋病毒的患者中,超声心动图检测到的心肌和心包疾病的患病率很高。没有扩张的左心功能不全是常见的,但其意义尚未确定。

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