Purpose. To evaluate whether 3T clinical MRI with a small-animal coil and gradient-echo (GE) sequence could be used to characterize long-term left ventricular remodelling (LVR) following nonreperfused myocardial infarction (MI) using semi-automatic segmentation software (SASS) in a rat model. Materials and Methods. 5 healthy rats were used to validate left ventricular mass (LVM) measured by MRI with postmortem values. 5 sham and 7 infarcted rats were scanned at 2 and 4 weeks after surgery to allow for functional and structural analysis of the heart. Measurements included ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and LVM. Changes in different regions of the heart were quantified using wall thickness analyses. Results. LVM validation in healthy rats demonstrated high correlation between MR and postmortem values. Functional assessment at 4 weeks after MI revealed considerable reduction in EF, increases in ESV, EDV, and LVM, and contractile dysfunction in infarcted and noninfarcted regions. Conclusion. Clinical 3T MRI with a small animal coil and GE sequence generated images in a rat heart with adequate signal-to-noise ratio (SNR) for successful semiautomatic segmentation to accurately and rapidly evaluate long-term LVR after MI.

译文

:目的。使用半自动分割软件(SASS)评估具有小动物线圈和梯度回波(GE)序列的3T临床MRI是否可用于表征非再灌注心肌梗死(MI)后的长期左心室重构(LVR)在大鼠模型中。材料和方法。使用5只健康大鼠通过验尸值验证通过MRI测量的左心室质量(LVM)。在手术后第2和第4周对5只假大鼠和7只梗塞的大鼠进行了扫描,以便对心脏进行功能和结构分析。测量包括射血分数(EF),舒张末期容积(EDV),收缩末期容积(ESV)和LVM。使用壁厚分析对心脏不同区域的变化进行定量。结果。在健康大鼠中的LVM验证表明MR和验尸值之间存在高度相关性。 MI后4周的功能评估显示,梗塞区和非梗塞区的EF明显降低,ESV,EDV和LVM升高,以及收缩功能障碍。结论。具有小动物线圈和GE序列的临床3T MRI在大鼠心脏中生成具有足够信噪比(SNR)的图像,可成功进行半自动分割,从而准确快速地评估MI后的长期LVR。

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