Malaria continues to be an increasing health concern in many endemic areas where it remains a major contributor to childhood morbidity and mortality. Chemoprophylaxis and treatment are increasingly compromised by drug resistance. Vaccination for malaria is not yet available outside clinical trials. In clinical trials bed nets have been shown to be effective in reducing malarial morbidity and mortality. Their efficacy outside of the clinical trial setting has been less well documented. We describe our experience with the introduction of bed nets in a remote rural Zambian village and document the effect on malarial parasitaemia, spleen rates and haemoglobin. Children were evaluated at the end of the rainy seasons in April 1998 and April 1999. Insecticide impregnated nets were made available for purchase to the village in July 1998. Rates of parasitaemia and anaemia were significantly reduced.

译文

疟疾在许多地方性流行地区仍然是日益严重的健康问题,在疟疾流行地区,疟疾仍然是造成儿童发病率和死亡率的主要因素。化学预防和治疗越来越受到耐药性的损害。除临床试验外,尚无针对疟疾的疫苗接种。在临床试验中,已证明蚊帐可有效降低疟疾发病率和死亡率。在临床试验环境之外的疗效还没有得到很好的证明。我们描述了在偏远的赞比亚农村村庄引入蚊帐的经验,并记录了其对疟疾寄生虫血症,脾脏率和血红蛋白的影响。在1998年4月和1999年4月的雨季结束时对儿童进行了评估。1998年7月,该村向村民购买了浸有杀虫剂的蚊帐。寄生虫血症和贫血的发生率大大降低了。

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