Recent advances in molecular biology have revolutionized the concept of KIT/PDGFRA wild type (WT) gastrointestinal stromal tumors (GIST) than the past. Indeed, from being defined as GIST without KIT or PDGFRA mutations, we are now faced with the opposite scenario, where KIT/PDGFRA WT GIST are "positively" defined according to their specific molecular alterations. In particular, if until recently KIT/PDGFRA GIST without abnormalities of KIT, PDGFRA, SDH, and the RAS signaling pathway were referred as quadruple WT GIST, today also this small subset of GIST is emerging out as a group of heterogeneous distinct entities with multiple different molecular alterations. Therefore, given this still growing and rapidly evolving scenario, the progressive molecular fragmentation may inevitably lead over the time to the disappearance of KIT/PDGFRA WT GIST, destined to be singularly defined by their molecular fingerprint.

译文

分子生物学的最新进展比过去彻底改变了KIT/PDGFRA野生型 (WT) 胃肠道间质瘤 (GIST) 的概念。实际上,从被定义为没有KIT或PDGFRA突变的GIST开始,我们现在面临相反的情况,即KIT/PDGFRA WT GIST根据其特定的分子变化被 “肯定” 定义。特别是,如果直到最近KIT/PDGFRA GIST没有KIT,PDGFRA,SDH和RAS信号通路异常被称为四重WT GIST,那么今天GIST的这一小部分也作为一组异质的不同实体出现,具有多种不同的分子改变。因此,鉴于这种仍在增长和快速发展的情况,渐进的分子断裂可能不可避免地导致随着时间的流逝,KIT/PDGFRA WT GIST的消失,注定要由其分子指纹单独定义。

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