The impact of depression on quality of life (QOL) and social support has neither been well characterized in clinical samples of women with perimenopausal depression (PMD) nor have the relative contributions of depression and other menopausal symptoms (e.g., hot flushes) to declining QOL been clarified. In this study, we compared QOL measures, social support, and functional disability in PMD and non-depressed perimenopausal women. We evaluated women aged 40-60 years who presented with menstrual cycle irregularity, elevated plasma FSH levels, and met criteria for perimenopause. A structured clinical interview was administered to determine the presence or absence of major and minor depression. Outcome measures included the Quality of Life Enjoyment Scale Questionnaire, the Sheehan Disability Scale, the Global Assessment of Functioning, the Social Adjustment Scale, and the Duke Social Support Index. Kruskal-Wallis tests and ANOVAs were used to compare outcome measures. Ninety women with PMD and 51 control women participated in this study. Women with PMD reported significantly decreased QOL, social support, and adjustment and increased disability compared with non-depressed perimenopausal women. Neither perimenopausal reproductive status alone nor the presence of hot flushes had a significant negative impact on QOL measures. PMD is accompanied by significant reductions in QOL, social support, and disability similar to depression in women at other stages of life. PMD may also contribute to decreased QOL in community- or clinic-based samples of perimenopausal women. It remains unclear whether the clinical characteristics we identified reflect pre-existing risk factors for depression during the perimenopause or the effects of a current depression. Future clinical and treatment studies in perimenopausal women should distinguish depressed women when outcome measures include QOL.

译文

抑郁症对生活质量 (QOL) 和社会支持的影响在围绝经期抑郁症 (PMD) 妇女的临床样本中既没有得到很好的表征,也没有抑郁症和其他更年期症状 (例如潮热) 的相对贡献。在这项研究中,我们比较了PMD和非抑郁的围绝经期妇女的QOL指标,社会支持和功能障碍。我们评估了40-60岁的女性,这些女性出现月经周期不规则,血浆FSH水平升高并符合围绝经期标准。进行了结构化的临床访谈,以确定是否存在重度和轻度抑郁症。结果指标包括生活质量享受量表问卷,Sheehan残疾量表,全球功能评估,社会适应量表和Duke社会支持指数。使用Kruskal-Wallis测试和ANOVAs比较结果指标。90名PMD妇女和51名对照妇女参加了这项研究。与非抑郁的围绝经期妇女相比,患有PMD的妇女报告的QOL,社会支持和适应能力显着降低,残疾增加。单独的围绝经期生殖状态或潮热的存在都不会对QOL措施产生重大负面影响。PMD伴随着生活质量,社会支持和残疾的显着降低,类似于处于其他生活阶段的女性的抑郁症。PMD也可能导致围绝经期妇女社区或临床样本的QOL降低。目前尚不清楚我们确定的临床特征是否反映了围绝经期抑郁症的先前存在的危险因素或当前抑郁症的影响。当结局指标包括QOL时,围绝经期妇女的未来临床和治疗研究应区分抑郁妇女。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录