SUMMARY STATEMENT:A 56-year-old woman presented with photopsia and color changes in the left eye that had been present since starting voriconazole treatment 5 months earlier. The patient was seen in ophthalmologic follow-up 7 and 20 months after discontinuation of voriconazole with persistent visual complaints, including photopsia and "additional sources of light" in her left eye. PURPOSE:To describe a case of persistent photopsia following course of oral voriconazole. METHODS:The medical records of a patient with voriconazole treatment and persistent photopsia were reviewed. RESULTS:Persistent photopsia and visual complaints were noted 20 months after discontinuation of voriconazole. CONCLUSIONS:In light of increasing use of voriconazole to combat fungal infections, voriconazole-related photopsia may persist in certain patients.