A homocysteine-independent role for B-group vitamins on venous thrombosis (VT) development has been reported. However, related research findings remain inconsistent. PUBMED, EMBASE, and COCHRANE databases were searched to collect information on all eligible studies to make a meta-analysis about the relationship between B-group vitamins and VT. Literature search results did not suggest a correlation between thiamin, pantothenic acid, niacin, or riboflavin with VT. Based on their correlations in the literature, folic acid, vitamin B12, B6 were considered in the meta-analysis and systematic review. Significant standardized mean differences were obtained for plasma folic acid (-0.55; 95% CI, -0.75 to -0.36) and vitamin B12 (-0.34; 95% CI, -0.55 to -0.13). Reduced levels of folic acid and vitamin B12 may be independent risk factors of VT. Moreover, a qualitative systematic review indicated that low level of vitamin B6 was an independent risk factor of VT. Randomized clinical studies of B-group vitamins supplementation showed varying results on VT prevention. Multivitamin supplementation for VT prevention, regardless of homocysteine level, would be of interest. Further prospective clinical studies are needed to provide additional evidence on the clinical benefits of B-group vitamin supplementation for VT.

译文

据报道,b族维生素在静脉血栓形成 (VT) 发展中的同型半胱氨酸独立作用。然而,相关的研究结果仍然不一致。搜索PUBMED,EMBASE和COCHRANE数据库以收集有关所有符合条件的研究的信息,以对B组维生素与VT之间的关系进行荟萃分析。文献搜索结果未表明硫胺素,泛酸,烟酸或核黄素与VT之间存在相关性。根据文献中的相关性,在荟萃分析和系统评价中考虑了叶酸,维生素B12,B6。血浆叶酸 (-0.55; 95% CI,-0.75至-0.36) 和维生素B12 (-0.34; 95% CI,-0.55至-0.13) 获得了显著的标准化平均差异。叶酸和维生素B12水平的降低可能是VT的独立危险因素。此外,定性系统评价表明,维生素B6水平低是VT的独立危险因素。补充B组维生素的随机临床研究显示,预防VT的结果各不相同。无论同型半胱氨酸水平如何,补充多种维生素可预防VT。需要进一步的前瞻性临床研究,以提供有关补充B组维生素对VT的临床益处的更多证据。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录