Elevated plasma asymmetric dimethylarginine (ADMA) concentrations have been suggested as a potential risk factor for cardiovascular disease (CVD). Studies indicate a linkage between hyperhomocysteinemia, oxidative stress and ADMA metabolism. We tested the hypothesis that combined supplementation of B vitamins and antioxidants reduces ADMA concentrations in subjects with at least two CVD risk factors. A total of 123 men and women (58+/-8.1 years) were randomly assigned to take either a preparation including B vitamins and antioxidants (verum) or placebo for 6 months in a double-blind design. Blood concentrations of ADMA, symmetric dimethylarginine (SDMA), L-arginine, B vitamins, total homocysteine (tHcy), alpha-tocopherol, antioxidant capacity (TEAC), and oxLDL were measured pre- and post-intervention. Treatment with verum significantly decreased tHcy (-2.14 micromol/L; P<0.001) and significantly increased TEAC values (+39.3 microM; P<0.022), but no effect on ADMA was observed. OxLDL was significantly reduced in verum (-7.3 U/L; P=0.001) and placebo (-9.2U/L; P<0.001). At baseline, significant correlations were found only between ADMA and SDMA (r=0.281; P=0.002), L-arginine/ADMA and SDMA (r=-0.294; P<0.001), L-arginine/ADMA and oxLDL (r=-0.281; P=0.016), and L-arginine/ADMA and age (r=-0.231; P=0.010). Our results indicate that combined supplementation of B vitamins and antioxidants is not an adequate strategy to reduce ADMA plasma levels in subjects with elevated CVD risk.

译文

血浆不对称二甲基精氨酸 (ADMA) 浓度升高已被认为是心血管疾病 (CVD) 的潜在危险因素。研究表明高同型半胱氨酸血症,氧化应激和ADMA代谢之间存在联系。我们检验了以下假设: 在至少有两种CVD危险因素的受试者中,复合补充b族维生素和抗氧化剂可降低ADMA浓度。在双盲设计中,总共123名男性和女性 (58 +/-8.1岁) 被随机分配服用包括b族维生素和抗氧化剂 (verum) 或安慰剂的制剂,为期6个月。在干预前后测量了ADMA,对称二甲基精氨酸 (SDMA),L-精氨酸,b族维生素,总同型半胱氨酸 (tHcy),α-生育酚,抗氧化能力 (TEAC) 和oxLDL的血液浓度。用verum处理显着降低tHcy (-2.14 micromol/L; P<0.001) 和显着增加TEAC值 (39.3 microM; P<0.022),但未观察到对ADMA的影响。在verum (-7.3 U/L; P = 0.001) 和安慰剂 (-9.2U/L; P<0.001) 中OxLDL显著降低。在基线时,仅发现ADMA和SDMA (r = 0.281; P = 0.002),L-精氨酸/ADMA和SDMA (r =-0.294; P<0.001),L-精氨酸/ADMA和oxLDL (r =-0.281; P = 0.016) 之间存在显着相关性,L-精氨酸/ADMA和年龄 (r =-0.231; P = 0.010)。我们的结果表明,在CVD风险升高的受试者中,联合补充b族维生素和抗氧化剂并不是降低ADMA血浆水平的适当策略。

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