We investigated whether a formulation containing vitamins and minerals (vit&min) could improve the worsening of mood changes occurring after delivery ("a.d."). The study was performed in 552 healthy non-anaemic puerperal women ("p.w") without risk factors for puerperal depression ("p.d"). They were at their first full-term pregnancy, and spontaneously delivered healthy newborns. The Edinburgh Depression Postnatal scale (EPDS) evaluates the psychological status of "p.w". EPDS was administered the 3rd (visit 1), 15th (visit 2) and 30th (visit 3) day "a.d.". An EPDS >12 indicates a major susceptibility to "p.d". At the same time intervals, haemoglobin, iron and ferritin (haematological parameters) levels were evaluated. After visit 1, the subjects were randomized to vit&min treatment (group A; N.274) or to calcium/vitamin D3 treatment (group B; N.278). In both groups haematological parameters significantly increased without differences between the groups. EPDS score improved in both groups, but in the group A, the EPDS decrease was significantly larger (p < 0.05) in comparison to the group B. This effect is mainly evident in subjects with a basal EPDS ≥ 12. An early examination of psychological condition could select "p.w." with a high susceptibility to neuronal changes occurring postpartum. Vit&min favourably modulates brain functions antagonizing the evolution to "p.d".
译文
我们调查了含有维生素和矿物质 (vit & min) 的制剂是否可以改善分娩后情绪变化的恶化 (“a.d.”)。该研究是在552名健康的非贫血产褥期妇女 (“p.w”) 中进行的,没有产褥期抑郁症 (“p.d”) 的危险因素。他们在第一次足月怀孕时,自发分娩了健康的新生儿。爱丁堡抑郁产后量表 (EPDS) 评估 “p.w” 的心理状况。EPDS在 “a.d.” 的第3天 (访视1),第15天 (访视2) 和第30天 (访视3) 进行了治疗。EPDS >12表示对 “p.d” 的主要易感性。在同一时间间隔,评估血红蛋白,铁和铁蛋白 (血液学参数) 水平。访视1后,受试者被随机分配接受vit & min治疗 (A组; N.274) 或钙/维生素D3治疗 (B组; N.278)。在两组中,血液学参数均显着增加,两组之间没有差异。两组的EPDS评分均有所改善,但与B组相比,A组的EPDS下降幅度明显更大 (p <0.05)。这种作用主要在基础EPDS ≥ 12的受试者中很明显。对心理状况的早期检查可以选择 “p.w.”。对产后发生的神经元变化高度敏感。Vit & min有利地调节大脑功能,拮抗进化为 “p.d”。