We studied antimutagenic effects of vitamins A and C (in recommended daily doses for 30 days) and their effects on the kinetics of human buccal epitheliocytes. Buccal swab specimens were collected in 29 students before and after vitamin course. The cytogenetic parameters (cells with micronuclei and protrusions) and parameters of proliferation (binuclear cells and cells with double nuclei) and nucleus destruction (karyopyknosis, karyorrhexis, karyolysis, etc.) were analyzed. The levels of cells with micronuclei and total level of cytogenetic disorders decreased by 38% after vitamin course, which confirmed their antimutagenic effect. A slight increase in the percentage of apoptotic cells seemed to reflect more active process of elimination of genetically damaged cells.

译文

我们研究了维生素a和C (推荐的每日剂量为30天) 的抗诱变作用及其对人颊上皮细胞动力学的影响。在维生素课程前后,在29名学生中收集了颊拭子标本。分析了细胞遗传学参数 (具有微核和突起的细胞) 和增殖参数 (双核细胞和具有双核的细胞) 和核破坏 (核分裂,核分裂,核分裂等)。维生素疗程后,具有微核的细胞水平和总细胞遗传学疾病水平降低了38%,这证实了它们的抗诱变作用。凋亡细胞百分比的轻微增加似乎反映了消除遗传损伤细胞的更积极的过程。

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