Vitamin D is suggested to have a role in the coupling of bone resorption and formation. Compared with women, men are believed to have more stable bone remodeling, and thus, are considered less susceptible to the seasonal variation of calcitropic hormones. We examined whether seasonal variation exists in calcitropic hormones, bone remodeling markers, and BMD in healthy men. Furthermore, we determined which vitamin D intake is required to prevent this variation. Subjects (N = 48) were healthy white men 21-49 yr of age from the Helsinki area with a mean habitual dietary intake of vitamin D of 6.6 +/- 5.1 (SD) microg/d. This was a 6-mo double-blinded vitamin D intervention study, in which subjects were allocated to three groups of 20 microg (800 IU), 10 microg (400 IU), or placebo. Fasting blood samplings were collected six times for analyses of serum (S-)25(OH)D, iPTH, bone-specific alkaline phosphatase (BALP), and TRACP. Radial volumetric BMD (vBMD) was measured at the beginning and end of the study with pQCT. Wintertime variation was noted in S-25(OH)D, S-PTH, and S-TRACP (p < 0.001, p = 0.012, and p < 0.05, respectively) but not in S-BALP or vBMD in the placebo group. Supplementation inhibited the winter elevation of PTH (p = 0.035), decreased the S-BALP concentration (p < 0.05), but benefited cortical BMD (p = 0.09) only slightly. Healthy men are exposed to wintertime decrease in vitamin D status that impacts PTH concentration. Vitamin D supplementation improved vitamin D status and inhibited the winter elevation of PTH and also decreased BALP concentration. The ratio of TRACP to BALP shows the coupling of bone remodeling in a robust way. A stable ratio was observed among those retaining a stable PTH throughout the study. A daily intake of vitamin D in the range of 17.5-20 microg (700-800 IU) seems to be required to prevent winter seasonal increases in PTH and maintain stable bone turnover in young, healthy white men.

译文

建议维生素d在骨吸收和形成的耦合中起作用。与女性相比,男性被认为具有更稳定的骨骼重塑,因此被认为不太容易受到钙调激素的季节性变化的影响。我们检查了健康男性的钙蛋白激素,骨重塑标志物和BMD是否存在季节性变化。此外,我们确定了需要摄入哪种维生素d来防止这种变化。受试者 (N = 48) 是来自赫尔辛基地区的21-49岁健康白人,平均习惯性饮食摄入的维生素d为6.6/- 5.1 (SD) microg/D。这是一项6个月的双盲维生素d干预研究,其中将受试者分配到三组20微克 (800 IU),10微克 (400 IU) 或安慰剂。空腹采血六次,以分析血清 (S-)25(OH)D,iPTH,骨特异性碱性磷酸酶 (BALP),和TRACP。在研究开始和结束时用pQCT测量径向体积BMD (vBMD)。在S-25(OH)D、S-PTH和S-TRACP中观察到冬季变化 (p <0.001,p = 0.012和p <0.05,但在安慰剂组的S-BALP或vBMD中没有。补充抑制冬季PTH升高 (p = 0.035),降低S-BALP浓度 (p <0.05),但对皮质骨密度 (p = 0.09) 仅略有益处。健康男性暴露于影响PTH浓度的维生素d状态的冬季降低。补充维生素d改善了维生素d状态,抑制了PTH的冬季升高,也降低了BALP浓度。TRACP与BALP的比率显示了骨重塑的耦合以一种稳健的方式。在整个研究中,在保持稳定的PTH的人群中观察到稳定的比例。每天摄入17.5-20微克 (700-800 IU) 的维生素d似乎需要防止冬季PTH季节性增加,并保持年轻时的稳定骨转换,健康的白人。

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