Arginine supplements were given to 6 week old CBA mice beginning 3 days prior to inoculation with a murine sarcoma virus, the Moloney Sarcoma Virus (MSV). Although the basal diet contained 1.8% arginine and was therefore not arginine-deficient, supplementation of the diet and the drinking water with 0.5% arginine HCl reduced tumor incidence, lengthened the latency period, decreased tumor size, and hastened tumor regression. Arginine also increased thymic weight and cellularity in normal and in MSV-inoculated mice. The antitumor action of arginine may be related to its effect on the thymus.

译文

在接种鼠肉瘤病毒莫洛尼肉瘤病毒 (MSV) 之前的3天,对6周龄的CBA小鼠给予精氨酸补充剂。尽管基础饮食含有1.8% 精氨酸,因此并不缺乏精氨酸,但饮食和饮用水中添加0.5% 精氨酸HCl可降低肿瘤发生率,延长潜伏期,减小肿瘤大小,并加速肿瘤消退。精氨酸还增加了正常和接种MSV的小鼠的胸腺重量和细胞性。精氨酸的抗肿瘤作用可能与其对胸腺的作用有关。

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