During embryogenesis, dental trigeminal axon navigation and patterning in the developing tooth take place in a highly spatio-temporally directed manner that is tightly linked to tooth morphogenesis and cell differentiation. Tooth formation is regulated by sequential and reciprocal tissue interactions between dental epithelium and neural crest-derived ectomesenchymal cells. This odontogenic secondary induction is mediated by signal molecules of different conserved families. Recent molecular and experimental data have provided evidence that local instructive signaling from the early odontogenic epithelium also controls dental axon navigation in the dental mesenchyme. In this review, we discuss recent molecular data regarding tooth formation and innervation and the putative role of the secondary induction in coordinating these two developmental processes. Importantly, because it has not yet been shown that the interactions that regulate tooth innervation include signaling to the dental epithelium and that they are reciprocal, it remains to be demonstrated that secondary induction controls the establishment of tooth nerve supply. Moreover, the key question of which molecule(s), if any, integrate tooth morphogenesis and the development of dental sensory trigeminal innervation remains to be answered.

译文

在胚胎发生过程中,发育中的牙齿中的三叉神经轴突导航和图案化以高度时空定向的方式发生,这与牙齿的形态发生和细胞分化紧密相关。牙齿形成受牙齿上皮与神经嵴来源的外胚间充质细胞之间的顺序和相互组织相互作用的调节。这种牙源性次级诱导是由不同保守家族的信号分子介导的。最近的分子和实验数据提供了证据,表明来自早期牙源性上皮的局部指导性信号也控制了牙间充质中的牙轴突导航。在这篇综述中,我们讨论了有关牙齿形成和神经支配的最新分子数据,以及次级诱导在协调这两个发育过程中的假定作用。重要的是,由于尚未显示出调节牙齿神经支配的相互作用包括对牙齿上皮的信号传导,并且它们是相互的,因此仍有待证明,二次诱导控制牙齿神经供应的建立。此外,哪个分子 (如果有的话) 整合牙齿形态发生和牙齿感觉三叉神经支配的发展的关键问题仍有待回答。

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