Euphorbia microsciadia (Euphorbiaceae) is a perennial plant growing in Iran. Two new cyclomyrsinol esters, 3-O-propionyl-5, 10, 14-O-triacetyl-8-O-(2'-methyl-butanoyl)-cyclomyrsinol (1) and 3, 5, 10, 14, 15-O-pentaacetyl-8-O-isobutanoyl-cyclomyrsinol (2) were isolated from the methanolic extract of its dried aerial parts. The structures were elucidated based on (13)C- and (1)H-NMR as well as 2D-NMR, IR and different MS spectra. Anti-angiogenic activity was also evaluated on vascular endothelium growth factor (VEGF)-induced angiogenesis in cultured human umbilical vein endothelial cells in vitro by assessing capillary-like tube network formation.

译文

大戟科 (Euphorbiaceae) 是一种多年生植物,生长在伊朗。从其干燥的地上部分的甲醇提取物中分离出两种新的环氨酚酯,3-o-丙酰基-5,10,14-O-triacetyl-8-O-(2 '-甲基-丁酰基)-环氨酚 (1) 和3,5,10,14,15-O-pentaacetyl-8-O-isobutanoyl-cyclomyrsinol (2)。基于 (13)C-和 (1) h-nmr以及2D-NMR,IR和不同的MS光谱阐明了结构。还通过评估毛细血管样管网络的形成,评估了体外培养的人脐静脉内皮细胞中血管内皮生长因子 (VEGF) 诱导的血管生成的抗血管生成活性。

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