In this study, we analyzed the VEGF and CD105 immunoexpression in 24 cervical squamous cell carcinomas and CIN associated lesions with different degrees. For both lesions, MVD values were higher in patients who had associated risk factors. VEGF and MVD expression increased in both categories for high-grade lesions, respectively CIN III lesions compared with CIN I/II and poorly differentiated carcinomas compared with well-differentiated ones. Also, there was a statistically significant association between VEGF and MVD in poorly differentiated carcinoma and CIN III. The study indicated that analyzed markers were specific for both early and advanced stages of cervical angiogenesis. Maximum values of VEGF and MVD in CIN III designate this lesion as critical to the progression of neoplasia.

译文

在这项研究中,我们分析了24种不同程度的宫颈鳞状细胞癌和CIN相关病变中的VEGF和CD105免疫表达。对于这两个病变,具有相关危险因素的患者的MVD值较高。高级别病变的两类VEGF和MVD表达均增加,分别是CIN III病变与CIN I/II相比,以及低分化癌与高分化癌相比。此外,在低分化癌和CIN III中,VEGF和MVD之间具有统计学上的显着相关性。研究表明,分析的标记物对宫颈血管生成的早期和晚期都具有特异性。CIN III中VEGF和MVD的最大值表示该病变对肿瘤的进展至关重要。

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