This study investigates whether salivary tumours with different morphology and evolution also differ in terms of neovascularization and VEGF expression and the prognostic value of the results. Surgical specimens from 45 patients - 8 pleomorphic adenomas (PA), 7 Warthin tumours (WT), 5 basal cell adenomas (BA), 6 carcinomas ex-pleomorphic adenoma (CEPA), 6 mucoepidermoid carcinomas (MEC), 5 acinic cell carcinomas (AC), 4 adenoid cystic carcinomas (ACC) and 4 adenocarcinomas not otherwise specified (ADK NOS) - were immunostained. In malignant salivary tumours, the following mean microvascular density (MVD) values were recorded (± SD = Standard Deviation): 27.61 (SD ± 2.27) in cases with CEPA, 27.08 (DS ± 7.81) in AC and 32.93 (SD ± 7.76) in ADK NOS, with lower values for MEC 24.31(SD ± 2.88) and for ACC 22.13 (SD ± 5.44). For benign tumours, an MVD of 35.71 (SD ± 2.09) was recorded in WT and lower average values in PA (MVD = 14.84; SD ± 4.86) and in BA (MVD = 23.96; SD ± 9.13). MVD did not correlate with the investigated clinicopathological parameters. The VEGF expression is significantly more important (p = 0.001) in malignant salivary tumours as compared with benign ones. The VEGF expression and the microvascularization in salivary gland tumours are important elements to be considered when formulating a diagnosis and assessing case evolutions in patients with such tumours.

译文

本研究调查了具有不同形态和演变的唾液肿瘤在新生血管形成和VEGF表达以及结果的预后价值方面是否也存在差异。45例患者的手术标本-8例多形性腺瘤 (PA),7例Warthin肿瘤 (WT),5例基底细胞腺瘤 (BA),6例非多形性腺瘤 (CEPA),6例粘液表皮样癌 (MEC),5例腺泡细胞癌 (AC),免疫染色了4例腺样囊性癌 (ACC) 和4例未指明的腺癌 (ADK NOS)。在恶性唾液肿瘤中,记录了以下平均微血管密度 (MVD) 值 (± SD = 标准差): CEPA病例为27.61 (SD ± 2.27),AC为27.08 (DS ± 7.81),ADK NOS为32.93 (SD ± 7.76),MEC 24.31(SD ± 2.88) 和ACC 22.13 (SD ± 5.44) 的值较低。对于良性肿瘤,在WT中记录了35.71的MVD (SD ± 2.09),在PA (MVD = 14.84; SD ± 4.86) 和BA (MVD = 23.96; SD ± 9.13) 中记录了较低的平均值。MVD与所研究的临床病理参数无关。与良性唾液肿瘤相比,恶性唾液肿瘤中VEGF表达明显更重要 (p = 0.001)。涎腺肿瘤中的VEGF表达和微血管形成是制定诊断和评估此类肿瘤患者病例演变时要考虑的重要因素。

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