Five dichlorinated 8-quinolinols (2,5- 5,6-, 3,5-, 3,7-, and 4,5-dichloro-8-quinolinol) were tested against Candida albicans and C. tropicalis in Sabouraud dextrose broth with and without bovine serum. The 5,6-, 3,5-, and 3,7-dichloro-8-quinolinols proved to be more effective than the control, 5-fluorocytosine. In cytotoxicity tests employing baby hamster kidney (BHK) cells, all test agents proved to be more cytotoxic than the control. However, the minimum inhibitory concentration (MIC) of 3,5-dichloro-8-quinolinol to both fungi was only one tenth the cytotoxic dose, suggesting that the compound may be useful as a topical or systemic antifungal agent.

译文

在具有和不具有牛血清的sabourad葡萄糖肉汤中,测试了五种二氯化的8-喹啉醇 (2,5- 5,6-,3,5-,3,7-和4,5-二氯-8-喹啉醇) 对白色念珠菌和热带假丝酵母。5,6-,3,5-和3,7-二氯-8-喹啉醇被证明比对照5-氟胞嘧啶更有效。在使用小仓鼠肾脏 (BHK) 细胞的细胞毒性测试中,所有测试剂均被证明比对照更具细胞毒性。然而,3,5-二氯-8-喹啉醇对两种真菌的最小抑制浓度 (MIC) 仅10分之1细胞毒性剂量,表明该化合物可用作局部或全身性抗真菌剂。

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