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Genetic studies have recently revealed a role for transforming growth factor-beta-1 (TGF-beta 1) and its receptors (TGF-beta Rs I and II as well as endoglin) in embryonic vascular assembly and in the establishment and maintenance of vessel wall integrity. The purpose of this review is threefoldfirst, to reassess previous studies on TGF-beta and endothelium in the light of these recent findings; second, to describe some of the well-established as well as controversial issues concerning TGF-beta and its regulatory role in angiogenesis; and third, to explore the notion of "context' with respect to TGF-beta and endothelial cell function. Although the focus of this review will be on the endothelium, other vascular wall cells are also likely to be important in the pathogenesis of the vascular lesions revealed by genetic studies.

译文

遗传研究最近揭示了转化生长因子-beta-1 (TGF-beta 1) 及其受体 (TGF-beta Rs I和II以及endoglin) 在胚胎血管组装以及血管壁完整性的建立和维持中的作用。这篇综述的目的是三重首先,根据这些最新发现重新评估先前关于TGF-β 和内皮的研究; 第二,描述一些关于TGF-β 及其在血管生成中的调节作用的公认的和有争议的问题; 第三,探讨TGF-β 和内皮细胞功能的 “背景” 概念。尽管本综述的重点将放在内皮上,但其他血管壁细胞也可能在遗传学研究揭示的血管病变的发病机理中很重要。

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