Interaction between a membrane oscillator generated by voltage-dependent ion channels and an intracellular calcium signal oscillator was present in the earliest models (1984 to 1985) using representations of the sarcoplasmic reticulum. Oscillatory release of calcium is inherent in the calcium-induced calcium release process. Those historical results fully support the synthesis proposed in the articles in this review series. The oscillator mechanisms do not primarily compete with each; they entrain each other. However, there is some asymmetry: the membrane oscillator can continue indefinitely in the absence of the calcium oscillator. The reverse seems to be true only in pathological conditions. Studies from tissue-level work and on the development of the heart also provide valuable insights into the integrative action of the cardiac pacemaker.

译文

由电压依赖性离子通道产生的膜振荡器与细胞内钙信号振荡器之间的相互作用存在于最早的模型 (1984 1985年) 中,使用肌浆网表示。钙的振荡释放是钙诱导的钙释放过程中固有的。这些历史结果完全支持本综述系列文章中提出的综合建议。振荡器机制并不主要与它们竞争; 它们相互夹带。但是,存在一些不对称性: 在没有钙振荡器的情况下,膜振荡器可以无限期地持续。相反的情况似乎只有在病理条件下才是正确的。来自组织水平工作和心脏发育的研究也为心脏起搏器的综合作用提供了有价值的见解。

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