The objective of this study was to investigate the expressions of angiogenic factors and elucidate their angiogenic and prognostic roles in hepatocellular carcinoma (HCC) with background of hepatitis B virus (HBV). We evaluated microvessel density (MVD) of HCC, and investigated immunohistochemical expression of vascular endothelial growth factor (VEGF), angiopoietins (Ang-1 and Ang-2), and matrix metalloproteinases-9 (MMP-9) in 67 specimens of surgically resected HCC, which were all positive for hepatitis B surface antigen. We investigated the relationship between their expressions and clinicopathological factors or prognosis. The microvessel density (MVD) of tumor tissue and surrounding normal liver tissue was 93.1 +/- 43.8/mm2 and 30.4 +/- 14.8/mm2, respectively. The MVD of well-differentiated HCC was significantly less than that of poorly differentiated HCC. MVD was positively correlated with VEGF and Ang-2 expression (P = 0.0023 and 0.0265, respectively). There was less tumor recurrence in low Ang-2 and low MMP-9 group than high Ang-2 and/or high MMP-9 group (P = 0.002). In Cox regression model, portal vein thrombus and intrahepatic metastasis was the risk factors of tumor recurrence (P = 0.003 and 0.001, respectively). Our study showed that the expression of VEGF and Ang-2 were positively correlated with MVD. Ang-2 expression and/or MMP-9 expression might be a significant predictive factor for recurrence after resection in HCC patients with the background of HBV.

译文

这项研究的目的是研究血管生成因子的表达,并阐明其在具有乙型肝炎病毒 (HBV) 背景的肝细胞癌 (HCC) 中的血管生成和预后作用。我们评估了HCC的微血管密度 (MVD),并在67例手术切除的HCC标本中研究了血管内皮生长因子 (VEGF),血管生成素 (Ang-1和Ang-2) 和基质metalloproteinases-9 (MMP-9) 的免疫组织化学表达。乙肝表面抗原。我们调查了它们的表达与临床病理因素或预后之间的关系。肿瘤组织和周围正常肝组织的微血管密度 (MVD) 分别为93.1 +/- 43.8/mm2和30.4 +/- 14.8/mm2。高分化HCC的MVD明显小于低分化HCC。MVD与VEGF和Ang-2表达呈正相关 (分别为P = 0.0023和0.0265)。低Ang-2和低MMP-9组的肿瘤复发率低于高Ang-2和/或高MMP-9组 (P = 0.002)。在Cox回归模型中,门静脉血栓和肝内转移是肿瘤复发的危险因素 (分别为P = 0.003和0.001)。我们的研究表明,VEGF和Ang-2的表达与MVD呈正相关。Ang-2表达和/或MMP-9表达可能是HBV背景的HCC患者切除后复发的重要预测因素。

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