We are developing biocompatible small-calibre vascular substitutes based on polymeric scaffolds that incorporate cell-matrix signals to enhance vascular cell attachment and function. Our graft scaffold comprises an outer electrostatically spun porous polyurethane layer seeded with smooth muscle cells, and a luminal polycaprolactone layer for endothelial cell attachment. Vascular cell adhesion properties of three vascular elastic fibre molecules, tropoelastin, fibrillin-1 and fibulin-5, have been defined, and adhesion fragments optimized. These fragments are being used to coat the scaffolds to enhance luminal endothelial cell attachment, and to regulate smooth muscle cell attachment and function. Tropoelastin-based cell seeding materials are also being developed. In this way, vascular cell-matrix biology is enhancing graft design.

译文

我们正在开发基于聚合物支架的生物相容性小口径血管替代物,该支架结合了细胞基质信号以增强血管细胞附着和功能。我们的移植支架包括一个外部静电纺丝多孔聚氨酯层,该层接种有平滑肌细胞,以及一个用于内皮细胞附着的内腔聚己内酯层。已经定义了三种血管弹性纤维分子 (原弹性蛋白,fibrillin-1和fibulin-5) 的血管细胞粘附特性,并优化了粘附片段。这些片段被用于涂覆支架,以增强管腔内皮细胞的附着,并调节平滑肌细胞的附着和功能。基于原弹性蛋白的细胞播种材料也正在开发中。通过这种方式,血管细胞基质生物学正在增强移植物的设计。

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