Effects of diethylstilbestrol (DES) treatment (30 daily i.m. injections) in reproductive function in the male rat were investigated. These functions were evaluated with sperm counts, motility, fertility, morphology, serum testosterone, and a number of biochemical tests in rat epididymis and vasa deferentia. DES treatment resulted in a 15% loss of body weight and a 60 to 90% loss of weight of testes, epididymis, and vas deferens. Sperm parameters and fertility were reduced to nil by DES treatment. Likewise, the majority of the biochemical measures were severely depressed by the DES treatment. In general, the measured parameters were less affected or recovered with either testosterone cotreatment or 60 days of recovery, showing the role of androgen in maintaining functional integrity and metabolism. However, sperm parameters and fertility did not recover with testosterone cotreatment, which differs from withdrawal of treatment.

译文

研究了己烯雌酚 (DES) 治疗 (每天30次i.m.注射) 对雄性大鼠生殖功能的影响。通过精子数量,运动能力,生育能力,形态,血清睾丸激素以及大鼠附睾和输精管的许多生化测试来评估这些功能。DES治疗导致15% 体重减轻,睾丸,附睾和输精管重量减轻60至90%。经DES处理,精子参数和生育力降低为零。同样,DES治疗严重抑制了大多数生化措施。通常,通过睾丸激素联合治疗或恢复60天,测得的参数受到的影响较小或恢复,表明雄激素在维持功能完整性和代谢中的作用。但是,睾丸激素联合治疗无法恢复精子参数和生育力,这与退出治疗不同。

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