The effects of neurokinin A (NKA) on freshly isolated smooth muscle cells from the rat vas deferens were investigated electrophysiologically. NKA (10(-7) M) prolonged the duration of action potentials without affecting resting potentials. Under voltage-clamp conditions, NKA (10(-7) M) suppressed an outward K+ current activated by depolarizing voltage steps. Substance P (SP, 10(-7) M) did not affect the K+ current, suggesting that NKA is more potent in suppressing the K+ current than SP is, as is also true for the contractions of smooth muscles of the rat vas deferens. The suppression of the K+ conductance now reported may contribute to NKA-induced smooth muscle contraction.

译文

通过电生理研究了神经激肽A (NKA) 对大鼠输精管新鲜分离的平滑肌细胞的影响。NKA (10(-7) M) 延长了动作电位的持续时间,而不影响静息电位。在电压钳位条件下,NKA (10(-7) M) 抑制了通过去极化电压阶跃激活的向外K电流。物质P (SP,10(-7) M) 不影响K电流,表明NKA比SP更能抑制K电流,这对于大鼠输精管平滑肌的收缩也是如此。现在报道的抑制K电导可能有助于NKA诱导的平滑肌收缩。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录