The methanolic extract of the leaves of C. mucronata was screened for anti-ulcer properties using animal models. On isolated guinea pig ileum the extract inhibited contractions evoked by acetylcholine, histamine and serotonin. The extract remarkably decreased the propulsive movement of gastrointestinal content. The extract exhibited significant anti-ulcer activity protecting rats from indomethacin, histamine and stress-induced ulcers. It inhibited the growth of both Gram-positive and Gram-negative microorganisms. The oral LD50 value of the extract in mice was estimated to be 8.5 +/- 0.35 g/kg. The results revealed that the plant C. mucronata has potential medicinal value as an anti-ulcer agent.

译文

使用动物模型筛选了C. mucronata叶片的甲醇提取物的抗溃疡特性。在离体豚鼠回肠上,提取物抑制乙酰胆碱,组胺和5-羟色胺引起的收缩。提取物显着降低了胃肠道内容物的推进运动。该提取物具有显着的抗溃疡活性,可保护大鼠免受吲哚美辛,组胺和应激性溃疡的侵害。它抑制革兰氏阳性和革兰氏阴性微生物的生长。提取物在小鼠中的口服LD50值估计为8.5 +/- 0.35 g/kg。结果表明,该植物作为抗溃疡剂具有潜在的药用价值。

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