Children exposed to valproate monotherapy in utero were evaluated with respect to neurological functioning, behavior, and additional educational needs, and the results were compared with those for age- and gender-matched controls exposed to carbamazepine and children with no prenatal exposure to antiepileptic drugs. We identified from the community-based pregnancy registry of Kuopio University Hospital area (1989-2000) all first-born and school-aged children exposed to valproate (N=13). Neurological and neuropsychological assessments were made clinically, and behavioral problems were assessed with the Conners' Teacher Rating Scale (CTRS). Eight children (62%) exposed to valproate and two (15%) each in the carbamazepine-exposed and nonexposed groups (P=0.022) required educational support. Minor dysmorphic features were noted in eight children (62%) exposed to valproate and in three children (23%) each in the carbamazepine-exposed and nonexposed groups. On CTRS, children exposed to valproate received higher scores, indicating behavioral problems. In our small but population-based study, all children exposed to valproate had minor, and some of them major, cognitive or neurological problems. This difference is clearly observed when assessing each child individually, but the many confounding factors explaining at least part of this difference are difficult to control and avoid in clinical practice. Larger studies with a prospective design are needed to confirm these findings.

译文

对宫内接受丙戊酸单药治疗的儿童进行了神经功能,行为和其他教育需求的评估,并将结果与接受卡马西平的年龄和性别匹配的对照以及产前未接触抗癫痫药物的儿童进行了比较。我们从库奥皮奥大学医院地区 (1989-2000) 的社区妊娠登记处确定了所有暴露于丙戊酸盐的第一胎和学龄儿童 (N = 13)。临床上进行了神经和神经心理学评估,并使用conners教师评定量表 (CTRS) 评估了行为问题。暴露于丙戊酸盐的八名儿童 (62% 名) 和卡马西平暴露和非暴露组 (P = 0.022) 中的两名 (15% 名) 需要教育支持。在暴露于丙戊酸钠的八名儿童 (62% 名) 和卡马西平暴露和非暴露组中的三名儿童 (23% 名) 中发现了轻微的畸形特征。在CTRS上,暴露于丙戊酸盐的儿童得分较高,表明行为问题。在我们的小型但基于人群的研究中,所有接触丙戊酸盐的儿童都有轻微的,其中一些有严重的认知或神经问题。在单独评估每个孩子时,可以清楚地观察到这种差异,但是许多混杂因素解释了这种差异的至少一部分,在临床实践中很难控制和避免。需要具有前瞻性设计的更大的研究来证实这些发现。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录