Concentrations of serum anti-Haemophilus influenzae type b (anti-Hib) capsular polysaccharide (CPS) >/=0.15 and >/=1.0 microgram/mL are widely used as surrogates for protection against invasive Hib disease. However, the relationship between serum anti-Hib CPS following immunization and protection against colonization is not known, making it difficult to evaluate new Hib vaccines or combination vaccines. In the Dominican Republic, nasopharyngeal swabs were collected from 546 9-month-old infants who had received Hib conjugate vaccine at ages 2, 4, and 6 months and from 600 unvaccinated infants of the same age. The prevalence of Hib colonization was lower among vaccinated infants than among unvaccinated infants (0.9% vs. 2.3%). Among vaccinated infants, protection against colonization was significantly correlated with anti-Hib CPS concentrations >/=5 microgram/mL 1 month following the third dose of vaccine. These results suggest that the concentration of serum anti-Hib CPS needed for protection against colonization is greater than that needed for protection for invasive disease.

译文

血清抗流感嗜血杆菌b型 (抗Hib) 荚膜多糖 (CPS) 的浓度>/= 0.15和>/= 1.0微克/毫升被广泛用作预防侵袭性Hib疾病的替代物。然而预防接种后血清抗Hib CPS与抗定植保护之间的关系尚不清楚,因此难以评估新的Hib疫苗或组合疫苗。在多米尼加共和国,从546名在2、4和6个月龄接受Hib结合疫苗的9个月大婴儿和600名同龄未接种疫苗的婴儿中收集鼻咽拭子。接种疫苗的婴儿中Hib定植的患病率低于未接种疫苗的婴儿 (0.9% 对2.3%)。在接种疫苗的婴儿中,在第三剂疫苗接种后1个月,抗定植的保护作用与抗Hib CPS浓度>/= 5微克/毫升显着相关。这些结果表明,预防定植所需的血清抗Hib CPS浓度高于预防侵袭性疾病所需的血清抗Hib CPS浓度。

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