Chronic hepatitis C virus (HCV) infection causes substantial morbidity and mortality in the United States. Testing and treatment of asymptomatic persons might avert progression to more advanced disease. In 1998, CDC published guidelines for HCV testing based on risk factors for infection; however, recent studies indicate that at least one half of all persons living with HCV infection in the United States are unaware of their infection status. To increase testing rates, in 2012 CDC recommended one-time testing of all persons born during 1945-1965. To better understand where and why persons with chronic HCV infection sought their initial testing, 2006-2010 data were analyzed from a survey conducted as part of the ongoing Chronic Hepatitis Cohort Study. Of 4,689 patients with HCV infection who responded to the survey, 60.4% reported that their initial HCV test occurred in a physician's office. CDC's risk-based indications (e.g., injection drug use and hemodialysis) were cited by 1,045 (22.3%) of the patients as reasons for testing, whereas clinical indications (e.g., abnormal liver function tests or liver-related symptoms such as jaundice) were cited by 2,121 (45.2%), suggesting that many HCV infections were identified only after the patient had become symptomatic. Promoting U. S. Preventive Services Task Force and CDC recommendations for testing and identifying strategies that help physicians implement HCV testing in their offices might help facilitate timely identification of HCV infection and reduce morbidity and mortality.

译文

在美国,慢性丙型肝炎病毒 (HCV) 感染会导致大量的发病率和死亡率。无症状者的检测和治疗可能会避免进展到更晚期的疾病。1998年,疾病预防控制中心发布了基于感染危险因素的HCV检测指南; 然而,最近的研究表明,在美国,至少有一半的HCV感染者不知道他们的感染状况。为了提高检测率,2012年疾病预防控制中心建议对1945-1965年期间出生的所有人进行一次性检测。为了更好地了解慢性HCV感染者在哪里以及为什么要进行初步测试,从正在进行的慢性肝炎队列研究的一部分进行的一项调查中分析了2006-2010的数据。在对调查做出回应的4,689例HCV感染患者中,60.4% 例报告说他们最初的HCV测试在医生办公室进行。1,045 (22.3%) 的患者引用CDC的基于风险的适应症 (例如,注射药物使用和血液透析) 作为测试的原因,而临床适应症 (例如,2,121 (45.2%) 引用了肝功能检查异常或肝脏相关症状 (例如黄疸),这表明仅在患者出现症状后才发现许多HCV感染。促进美国预防服务工作组和疾病预防控制中心的检测和识别策略的建议,帮助医生在其办公室实施HCV检测,可能有助于及时识别HCV感染,降低发病率和死亡率。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录