Relationships between eating and affective disorders remain complex and unclear. Brain glucose metabolism of anorectic patients has been demonstrated to be reduced both globally and regionally, with a particular relative hypometabolism in the parietal cortex. To explore the possible influence of weight loss or depressive symptomatology on brain metabolism, we studied age- and sex-matched low-weight anorectic and depressed patients, normal-weight depressed patients, and healthy volunteers. Absolute global and regional glucose activity levels were reduced in low-weight patients, with the lowest values being found for anorectic patients. In relative values, anorectic patients showed a significant parietal hypometabolism in comparison to control subjects while they had higher metabolism in the caudate nuclei when compared with the other groups. Absolute hypometabolism of glucose seems to be a consequence of low weight as it was found in both low-weight anorectic and low-weight depressive patients. In addition, absolute glucose values were significantly correlated with body mass index in all subjects. Future positron emission tomographic studies in psychiatric patients should control for alimentary parameters.

译文

饮食和情感障碍之间的关系仍然复杂且不清楚。厌食症患者的脑葡萄糖代谢已被证明在全球和区域范围内均降低,顶叶皮层中存在特定的相对低代谢。为了探讨体重减轻或抑郁症状对大脑代谢的可能影响,我们研究了年龄和性别相匹配的低体重厌食和抑郁症患者,正常体重的抑郁症患者以及健康志愿者。低体重患者的绝对全球和区域葡萄糖活性水平降低,厌食症患者的最低值。在相对值中,与对照组相比,厌食患者表现出明显的顶叶代谢低下,而与其他组相比,他们在尾状核中的代谢更高。葡萄糖的绝对低代谢似乎是低体重的结果,因为在低体重的厌食症和低体重的抑郁症患者中都发现了它。此外,在所有受试者中,绝对葡萄糖值与体重指数显着相关。未来精神病患者的正电子发射断层扫描研究应控制饮食参数。

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