A questionnaire study of drug use and life-style among college seniors, previously performed in 1969, was repeated at the same college in 1978 with identical methods. Moderate increases in marijuana use were found; cocaine use had increased dramatically; most other drug use changed only slightly. Differences between users and nonusers, already modest in 1969, had narrowed further by 1978users and nonusers were indistinguishable on grades, athletics, other college activities, career plans, and subjective alienation. Only heterosexual activity and visits to a psychiatrist still distinguish users from nonusers.