Pyodermatitis-pyostomatitis vegetans (PPV) constitutes an inflammatory mucocutaneous dermatosis that is associated with inflammatory bowel disease. Clinically, PPV appears as pustules on mucosal surfaces and as vegetating exudative plaques on intertriginous surfaces. It is typically a clinical diagnosis supported by histological findings. Microscopic findings include epidermal hyperplasia, focal acantholysis, and a dense mixed inflammatory infiltrate with intraepithelial and subepithelial eosinophilic microabscesses. In the recent literature, immunofluorescence has been thought to be negative in PPV or, if positive, an aberrant finding. Herein, we report 2 cases of PPV associated with inflammatory bowel disease, which display intercellular IgA deposits. Although these cases may represent isolated epiphenomena, it is possible that the paucity of PPV cases with immunofluorescent studies hitherto has led to an oversight of an interesting association between intercellular IgA and PPV.

译文

脓性皮炎-脓性口炎 (PPV) 构成炎症性粘膜皮肤皮肤病,与炎症性肠病有关。临床上,PPV表现为粘膜表面的脓疱和三叉间表面的植被渗出性斑块。通常是由组织学发现支持的临床诊断。显微镜检查结果包括表皮增生,局灶性棘层松解和上皮内和上皮下嗜酸性微脓肿的致密混合炎性浸润。在最近的文献中,免疫荧光被认为在PPV中是阴性的,或者如果是阳性的,则是异常的发现。在此,我们报告了2例与炎症性肠病相关的PPV病例,这些病例显示出细胞间IgA沉积。尽管这些病例可能代表孤立的现象,但迄今为止,通过免疫荧光研究的PPV病例很少,这可能导致对细胞间IgA和PPV之间有趣的关联的监督。

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