Due to limited available therapeutic options, developing new lead compounds against hepatitis C virus is an urgent need. Human La protein stimulates hepatitis C virus translation through interaction with the hepatitis C viral RNA. A cyclic peptide mimicking the β-turn of the human La protein that interacts with the viral RNA was synthesized. It inhibits hepatitis C viral RNA translation significantly better than the corresponding linear peptide at longer post-treatment times. The cyclic peptide also inhibited replication as measured by replicon RNA levels using real time RT-PCR. The cyclic peptide emerges as a promising lead compound against hepatitis C.

译文

由于可用的治疗选择有限,迫切需要开发新的抗丙型肝炎病毒的领先化合物。人La蛋白通过与丙型肝炎病毒RNA相互作用刺激丙型肝炎病毒翻译。合成了模拟与病毒RNA相互作用的人La蛋白的 β-转的环肽。在较长的治疗后时间,它对丙型肝炎病毒RNA翻译的抑制作用明显优于相应的线性肽。环肽还抑制复制,如使用实时rt-pcr通过复制子RNA水平测量的那样。环肽作为抗丙型肝炎的有前途的铅化合物出现。

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