Inflammation affects the reliability of ferritin. The serum level of transferrin receptor protein (sTfR) represents true demand of iron in the body. This study attempts to identify levels of sTfR and correlate the trends of sTfR/ferritin index with BMI in the population of Karachi. 132 gender matched volunteers between the ages of 20-60 years were recruited for this cross-sectional study. BMI was calculated using the formula: (weight in kg / height in m2). Following groups were made according to South Asian criteria of BMI; Group A: normal weight (18.0-22.9 kg/m2), Group B: overweight (23.0-24.9 kg/m2), Group C: obese (>25.0 kg/m2). Serum ferritin, sTfR and CRP levels were determined using ELISA kits. Statistical comparisons were performed using Mann Whitney U and Spearman's rank correlation, where p<0.05 was considered significant. The results identified increased in TIBC, sTfR, ferritin and CRP in obese as compared to normal weight individuals (p<0.001). sTfR/ferritin ratio was 0.822 which signifies increased risk of acute myocardial infarction in group C. Serum iron (r=-0.359,p=0.004) showed negative correlation with BMI while serum ferritin (r=0.237,p< 0.001) and sTfR (r=0.263,p= 0.036) levels were positively associated to BMI. This study highlights a novel finding that sTfR is most likely a better clinical measure of iron status in inflammatory conditions as its expression is effected by erythropoiesis and not by inflammation. Risk of Acute myocardial infarction can also be predicted by increased sTfR/ferritin ratio.

译文

炎症影响铁蛋白的可靠性。血清转铁蛋白受体蛋白 (sTfR) 水平代表体内铁的真正需求。这项研究试图确定sTfR的水平,并将sTfR/铁蛋白指数的趋势与卡拉奇人口的BMI相关联。这项横断面研究招募了132名年龄在20-60岁之间的性别匹配志愿者。BMI的计算公式为 :( 体重kg/身高m2)。根据南亚BMI标准分为以下组; A组: 正常体重 (18.0-22.9千克/m2),B组: 超重 (23.0-24.9千克/m2),C组: 肥胖 (> 25.0千克/m2)。使用ELISA试剂盒测定血清铁蛋白,sTfR和CRP水平。使用Mann Whitney U和Spearman秩相关进行统计比较,其中p<0.05被认为是显著的。结果表明,与正常体重个体相比,肥胖者的TIBC,sTfR,铁蛋白和CRP升高 (p<0.001)。0.822了sTfR/铁蛋白比值,这表明C组发生急性心肌梗死的风险增加。血清铁 (r =-0.359,p = 0.004) 与BMI呈负相关,而血清铁蛋白 (r = 0.237,p< 0.001) 和sTfR (r = 0.263,p = 0.036) 与BMI呈正相关。这项研究强调了一项新发现,即sTfR最有可能是炎症条件下铁状态的更好的临床指标,因为其表达受红细胞生成而不是炎症影响。急性心肌梗死的风险也可以通过增加sTfR/铁蛋白比率来预测。

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