The purpose of the study was to assess knowledge and beliefs regarding vaccines and willingness to participate in HIV vaccine trials. A baseline survey assessed knowledge and attitudes toward vaccination and potential HIV vaccines among 14,177 participants aged 15-49 years, in a population cohort. Willingness to participate in HIV-preventive vaccine trials was assessed during a follow-up survey 10 months later after providing community education on HIV vaccines. Knowledge of the preventive utility of vaccines was high (71%), but higher in men than women (P<0.001), and increased with education levels (P<0.001). Vaccines were considered appropriate for children and women (99 and 88%, respectively), but not for adult men (28%). Participants felt that adolescents were the most appropriate subjects for HIV preventive vaccine trials (93.7%) but also thought that HIV-positive persons were eligible for trials (60.2%), and only 20% thought a preventive vaccine could help control HIV. HIV vaccine awareness increased from 68% at baseline to 81% at follow-up (P<0.001). Willingness to participate in HIV-preventive vaccine trials was 77%. Vaccine knowledge and willingness to participate in trials are high in this population. However, there still is need for education on the potential role of preventive HIV vaccines in the control of the epidemic and the importance of vaccination for men, especially in the context of an HIV vaccine.

译文

该研究的目的是评估有关疫苗的知识和信念以及参与HIV疫苗试验的意愿。一项基线调查评估了14,177名年龄在15-49岁之间的参与者对疫苗接种和潜在HIV疫苗的知识和态度。在提供艾滋病毒疫苗社区教育后10个月的后续调查中,评估了参与艾滋病毒预防疫苗试验的意愿。对疫苗的预防效用的了解很高 (71%),但男性高于女性 (P<0.001),并且随着教育水平的提高 (P<0.001)。疫苗被认为适用于儿童和妇女 (分别为99和88%),但不适用于成年男子 (28%)。参与者认为青少年是最适合进行HIV预防疫苗试验的对象 (93.7%),但也认为HIV阳性的人有资格进行试验 (60.2%),只有20% 认为预防性疫苗可以帮助控制HIV。HIV疫苗意识从基线时的68% 提高到随访时的81% (P<0.001)。77% 了参与艾滋病毒预防疫苗试验的意愿。在这一人群中,疫苗知识和参与试验的意愿很高。然而,仍然需要就预防性艾滋病毒疫苗在控制这一流行病中的潜在作用以及对男子接种疫苗的重要性进行教育,特别是在艾滋病毒疫苗的背景下。

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