Ubiquinone is a lipid antioxidant, and a novel liquid ubiquinol (a hydro-soluble, reduced form of coenzyme Q10) supplement was recently developed. The purpose of this study was to examine the levels of glucose, lipids and antioxidant capacity of type 2 diabetes patients after liquid ubiquinol supplementation. This study was designed as a randomised, double-blind, placebo-controlled trial. In all, fifty participants were randomly assigned to a placebo (n 25) or liquid ubiquinol (100 mg/d, n 25) group, and the intervention lasted for 12 weeks. Plasma coenzyme Q10, glucose homoeostasis parameters, lipid profiles, oxidative stress and antioxidative enzyme activities were measured during the study. After 12 weeks of supplementation, glyco Hb (HbA1c) value was significantly decreased in the liquid ubiquinol group (P=0·03), and subjects in the liquid ubiquinol group had significantly lower anti-glycaemic medication effect scores (MES) compared with those in the placebo group (P=0·03). The catalase (P<0·01) and glutathione peroxidase (P=0·03) activities were increased significantly after supplementation. Plasma coenzyme Q10 was correlated with the insulin level (P=0·05), homoeostatic model assessment-insulin resistance (P=0·07), quantitative insulin sensitivity check index (P=0·03) and the anti-hyperglycaemic agents' MES (P=0·03) after supplementation. Lipid profiles did not change after supplementation; however, the subjects in the placebo group had a significantly lower level of HDL-cholesterol after 12 weeks of intervention. In conclusion, oral intake of 100 mg/d liquid ubiquinol might benefit type 2 diabetes patients by increasing antioxidant enzyme activity levels, reducing HbA1c levels and maintaining HDL-cholesterol levels.

译文

泛醌是一种脂质抗氧化剂,最近开发了一种新型液体泛醌 (辅酶Q10的水溶性还原形式) 补充剂。这项研究的目的是检查补充液体泛醇后2型糖尿病患者的葡萄糖,脂质和抗氧化能力水平。这项研究被设计为一项随机,双盲,安慰剂对照试验。共有50名参与者被随机分配到安慰剂 (n 25) 或液体泛醇 (100 mg/d,n 25) 组,干预持续12周。在研究过程中测量了血浆辅酶Q10,葡萄糖稳态参数,脂质分布,氧化应激和抗氧化酶活性。补充12周后,液体泛醇组glyco Hb (HbA1c) 值显著降低 (P = 0·03),与安慰剂组相比,液体泛醇组的受试者抗血糖作用评分 (MES) 明显降低 (P = 0·03)。添加后,过氧化氢酶 (P<0·01) 和谷胱甘肽过氧化物酶 (P = 0·03) 活性显着增加。补充血浆辅酶Q10与胰岛素水平 (P = 0·05) 、胰岛素抵抗 (P = 0·07) 、胰岛素敏感性定量检查指数 (P = 0·03) 和抗高血糖药的MES (P = 0·03) 相关。补充后血脂谱没有变化; 然而,安慰剂组的受试者在干预12周后HDL-胆固醇水平明显降低。总之,口服摄入100 mg/d液体泛醇可能通过增加抗氧化酶活性水平,降低HbA1c水平和维持HDL-胆固醇水平而有益于2型糖尿病患者。

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